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New publication - Hyperplex PCR enables highly multiplexed analysis of point mutations in wastewater

Publications

23 jan. 2025

New publication - Hyperplex PCR enables highly multiplexed analysis of point mutations in wastewater

This study highlights hpPCR’s role in swift SARS-CoV-2 variant tracking in Swedish wastewater.

The publication, produced in collaboration with SEEC, showcases a full year of SARS-CoV-2 variant tracking in Swedish wastewater using hpPCR. This study demonstrates how hpPCR successfully fills the bioanalytical method gap between qPCR/dPCR and NGS, upgrading the current WBE analytical toolbox by providing: 


  1. High multiplexity per sample with single nucleotide specificity

  2. NGS-grade mutation frequency quantification with a good correlation (r = 0.88) extremely high linearity (R2 > 0.99) 

  3. 4-weeks+ early detection of variants of concern demonstrated vs sequencing 

  4. Panel customization with new probes within 2 weeks without panel re-optimization. 


Read the full article Hyperplex PCR enables highly multiplexed analysis of point mutations in wastewater: long-term SARS-CoV-2 variant surveillance in Sweden as a case study

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